Brain serotonin 1A receptor binding: relationship to peripheral blood DNA methylation, recent life stress and childhood adversity in unmedicated major depression.

ABSTRACT:

Background

Childhood and lifetime adversity may reduce brain serotonergic (5-HT) neurotransmission by epigenetic mechanisms.

Aims

We tested the relationships of childhood adversity and recent stress to serotonin 1A (5-HT_1A) receptor genotype, DNA methylation of this gene in peripheral blood monocytes and in vivo 5-HT_1A receptor binding potential (BP_F) determined by positron emission tomography (PET) in 13 a priori brain regions, in participants with major depressive disorder (MDD) and healthy volunteers (controls).

Method

Medication-free participants with MDD (n = 192: 110 female, 81 male, 1 other) and controls (n = 88: 48 female, 40 male) were interviewed about childhood adversity and recent stressors and g

SUBMITTER: Galfalvy H 

PROVIDER: S-EPMC10514224 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature