Heritability of amygdala reactivity to angry faces and its replicable association with the schizophrenia risk locus of miR-137.

ABSTRACT:

Background

Among healthy participants, the interindividual variability of brain response to facial emotions is associated with genetic variation, including common risk variants for schizophrenia, a heritable brain disorder characterized by anomalies in emotion processing. We aimed to identify genetic variants associated with heritable brain activity during processing of facial emotions among healthy participants and to explore the impact of these identified variants among patients with schizophrenia.

Methods

We conducted a data-driven stepwise study including samples of healthy twins, unrelated healthy participants and patients with schizophrenia. Participants approached or avoided pictures of faces with negative emotional valence during functional magnetic resonance imaging

SUBMITTER: Quarto T 

PROVIDER: S-EPMC10521919 | biostudies-literature | 2023 Sep-Oct

REPOSITORIES: biostudies-literature