Changes to hypothalamic volume and associated subunits during gender-affirming hormone therapy.

ABSTRACT:

Background

Among its pleiotropic properties, gender-affirming hormone therapy (GHT) affects regional brain volumes. The hypothalamus, which regulates neuroendocrine function and associated emotional and cognitive processes, is an intuitive target for probing GHT effects. We sought to assess changes to hypothalamus and hypothalamic subunit volumes after GHT, thereby honouring the region's anatomical and functional heterogeneity.

Methods

Individuals with gender dysphoria and cisgender controls underwent 2 MRI measurements, with a median interval of 145 days (interquartile range [IQR] 128.25-169.75 d, mean 164.94 d) between the first and second MRI. Transgender women (TW) and transgender men (TM) underwent the first MRI before GHT and the second MRI after approximately 4.5 mont

SUBMITTER: Konadu ME 

PROVIDER: S-EPMC10521920 | biostudies-literature | 2023 Sep-Oct

REPOSITORIES: biostudies-literature