Herpesvirus latent infection promotes stroke via activating the OTUD1/NF-κB signaling pathway.

ABSTRACT:

Objective

Our study aimed to reveal the molecular mechanisms underlying the regulation of cerebral infarction by herpes virus latency infection via the OTUD1/NF-κB signaling pathway using evidence-based medicine Meta-analysis and bioinformatics analysis.

Methods

We conducted a Meta-analysis by searching Pubmed, Embase, and Web of Science databases to evaluate the correlation between herpes virus infection and increased risk of cerebral infarction. We obtained wild-type or mutant herpes virus latent infection-related brain tissue datasets from the GEO database and performed differential analysis to identify differentially expressed genes (DEGs) in the brain tissue after herpes virus latent infection. We further conducted WGCNA co-expression analysis on the cerebral infarction

SUBMITTER: Lin J 

PROVIDER: S-EPMC10522389 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature