Adolescent exposure to low-dose THC disrupts energy balance and adipose organ homeostasis in adulthood.

ABSTRACT: One of cannabis' most iconic effects is the stimulation of hedonic high-calorie eating-the "munchies"-yet habitual cannabis users are, on average, leaner than non-users. We asked whether this phenotype might result from lasting changes in energy balance established during adolescence, when use of the drug often begins. We found that daily low-dose administration of cannabis' intoxicating constituent, Δ⁹-tetrahydrocannabinol (THC), to adolescent male mice causes an adult metabolic phenotype characterized by reduced fat mass, increased lean mass and utilization of fat as fuel, partial resistance to diet-induced obesity and dyslipidemia, enhanced thermogenesis, and impaired cold- and β-adrenergic receptor-stimulated lipolysis. Further analyses revealed that this phenotype is associ

SUBMITTER: Lin L 

PROVIDER: S-EPMC10524841 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature