Incorporation of natriuretic peptides with clinical risk scores to predict heart failure among individuals with dysglycaemia.

ABSTRACT:

Aims

To evaluate the performance of the WATCH-DM risk score, a clinical risk score for heart failure (HF), in patients with dysglycaemia and in combination with natriuretic peptides (NPs).

Methods and results

Adults with diabetes/pre-diabetes free of HF at baseline from four cohort studies (ARIC, CHS, FHS, and MESA) were included. The machine learning- [WATCH-DM(ml)] and integer-based [WATCH-DM(i)] scores were used to estimate the 5-year risk of incident HF. Discrimination was assessed by Harrell's concordance index (C-index) and calibration by the Greenwood-Nam-D'Agostino (GND) statistic. Improvement in model performance with the addition of NP levels was assessed by C-index and continuous net reclassification improvement (NRI). Of the 8938 participants included, 3554 (39.8

SUBMITTER: Segar MW 

PROVIDER: S-EPMC10535364 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature