Ethanolic Extract of Polygonum minus Protects Differentiated Human Neuroblastoma Cells (SH-SY5Y) against H₂O₂-Induced Oxidative Stress.

ABSTRACT: Neuronal models are an important tool in neuroscientific research. Hydrogen peroxide (H₂O₂), a major risk factor of neuronal oxidative stress, initiates a cascade of neuronal cell death. Polygonum minus Huds, known as 'kesum', is widely used in traditional medicine. P. minus has been reported to exhibit a few medicinal and pharmacological properties. The current study aimed to investigate the neuroprotective effects of P. minus ethanolic extract (PMEE) on H₂O₂-induced neurotoxicity in SH-SY5Y cells. LC-MS/MS revealed the presence of 28 metabolites in PMEE. Our study showed that the PMEE provided neuroprotection against H₂O₂-induced oxidative stress by activating the Nrf2/ARE, NF-κB/IκB and MAPK signaling

SUBMITTER: Sayuti NH 

PROVIDER: S-EPMC10535396 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature