CD4⁺ T Cell Responses to Toxoplasma gondii Are a Double-Edged Sword.

ABSTRACT: CD4⁺ T cells have been found to play critical roles in the control of both acute and chronic Toxoplasma infection. Previous studies identified a protective role for the Toxoplasma CD4⁺ T cell-eliciting peptide AS15 (AVEIHRPVPGTAPPS) in C57BL/6J mice. Herein, we found that immunizing mice with AS15 combined with GLA-SE, a TLR-4 agonist in emulsion adjuvant, can be either helpful in protecting male and female mice at early stages against Type I and Type II Toxoplasma parasites or harmful (lethal with intestinal, hepatic, and spleen pathology associated with a storm of IL6). Introducing the universal CD4⁺ T cell epitope PADRE abrogates the harmful phenotype of AS15. Our findings demonstrate quantitative and qualitative features of an effec

SUBMITTER: El Bissati K 

PROVIDER: S-EPMC10535856 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature