Ontology highlight
ABSTRACT:
SUBMITTER: Bucci J
PROVIDER: S-EPMC10540199 | biostudies-literature | 2023 Sep
REPOSITORIES: biostudies-literature
Bucci Juliette J Irmisch Patrick P Del Grosso Erica E Seidel Ralf R Ricci Francesco F
Journal of the American Chemical Society 20230914 38
Inspired by naturally occurring regulatory mechanisms that allow complex temporal pulse features with programmable delays, we demonstrate here a strategy to achieve temporally programmed pulse output signals in DNA-based strand displacement reactions (SDRs). To achieve this, we rationally designed input strands that, once bound to their target duplex, can be gradually degraded, resulting in a pulse output signal. We also designed blocker strands that suppress strand displacement and determine th ...[more]