Derivation, Validation, and Clinical Relevance of a Pediatric Sepsis Phenotype With Persistent Hypoxemia, Encephalopathy, and Shock.

ABSTRACT:

Objectives

Untangling the heterogeneity of sepsis in children and identifying clinically relevant phenotypes could lead to the development of targeted therapies. Our aim was to analyze the organ dysfunction trajectories of children with sepsis-associated multiple organ dysfunction syndrome (MODS) to identify reproducible and clinically relevant sepsis phenotypes and determine if they are associated with heterogeneity of treatment effect (HTE) to common therapies.

Design

Multicenter observational cohort study.

Setting

Thirteen PICUs in the United States.

Patients

Patients admitted with suspected infections to the PICU between 2012 and 2018.

Interventions

None.

Measurements and main results

We used subgraph-augmented nonnegative matrix factorization

SUBMITTER: Sanchez-Pinto LN 

PROVIDER: S-EPMC10540758 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature