Epidemiology of Modic changes in dogs: Prevalence, possible risk factors, and association with spinal phenotypes.

ABSTRACT:

Background

Chronic low back pain, a leading contributor to disease burden worldwide, is often caused by intervertebral disc (IVD) degeneration. Modic changes (MCs) are MRI signal intensity changes due to lesions in vertebral bone marrow adjacent to degenerated IVDs. Only a few studies described the histopathological changes associated with MC to date. MC type 1 is suggested to be associated with bone marrow infiltration of fibrovascular tissue, type 2 with fatty infiltration, and type 3 with bone sclerosis in humans.

Methods

This study investigated whether the dog can be a valuable animal model to research MCs, by examining the prevalence, imaging, and histological characteristics of lumbar MCs in dogs (340 dogs, 2496 spinal segments).

Results

Logistic regression anal

SUBMITTER: Beukers M 

PROVIDER: S-EPMC10540828 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature