Allele-specific regulatory effects on the pig transcriptome.

ABSTRACT:

Background

Allele-specific expression (ASE) refers to the preferential expression of one allele over the other and contributes to adaptive phenotypic plasticity. Here, we used a reciprocal cross-model between phenotypically divergent European Berkshire and Asian Tibetan pigs to characterize 2 ASE classes: imprinting (i.e., the unequal expression between parental alleles) and sequence dependent (i.e., unequal expression between breed-specific alleles). We examined 3 transcript types, including protein-coding genes (PCGs), long noncoding RNAs, and transcripts of unknown coding potential, across 7 representative somatic tissues from hybrid pigs generated by reciprocal crosses.

Results

We identified a total of 92 putative imprinted transcripts, 69 (75.00%) of which are described

SUBMITTER: Lin Y 

PROVIDER: S-EPMC10541795 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature