Myelination and excitation-inhibition balance synergistically shape structure-function coupling across the human cortex.

ABSTRACT: Recent work has demonstrated that the relationship between structural and functional connectivity varies regionally across the human brain, with reduced coupling emerging along the sensory-association cortical hierarchy. The biological underpinnings driving this expression, however, remain largely unknown. Here, we postulate that intracortical myelination and excitation-inhibition (EI) balance mediate the heterogeneous expression of structure-function coupling (SFC) and its temporal variance across the cortical hierarchy. We employ atlas- and voxel-based connectivity approaches to analyze neuroimaging data acquired from two groups of healthy participants. Our findings are consistent across six complementary processing pipelines: 1) SFC and its temporal variance respectively decrease and in

SUBMITTER: Fotiadis P 

PROVIDER: S-EPMC10542365 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature