Sex differences in associations between APOE ε2 and longitudinal cognitive decline.

ABSTRACT:

Introduction

We examined whether sex modifies the association between APOE ε2 and cognitive decline in two independent samples.

Methods

We used observational data from cognitively unimpaired non-Hispanic White (NHW) and non-Hispanic Black (NHB) adults. Linear mixed models examined interactive associations of APOE genotype (ε2 or ε4 carrier vs. ε3/ε3) and sex on cognitive decline in NHW and NHB participants separately.

Results

In both Sample 1 (N = 9766) and Sample 2 (N = 915), sex modified the association between APOE ε2 and cognitive decline in NHW participants. Specifically, relative to APOE ε3/ε3, APOE ε2 protected against cognitive decline in men but not women. Among APOE ε2 carriers, men had slower decline than women. Among APOE ε3/ε3 carriers, cognitive trajecto

SUBMITTER: Wood ME 

PROVIDER: S-EPMC10544702 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature