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Microwave assisted one-pot access to pyrazolo quinolinone and tetrahydroisoxazolo quinolinone derivatives via T3P®-DMSO catalysed tandem oxidative-condensation reaction.

ABSTRACT: A new approach for the synthesis of two important annulated pyrazolo quinolinone and tetrahydroisoxazolo quinolinone derivatives from multicomponent reactions was achieved by using T3P®-DMSO-catalysed reactions of stable alcohols, cyclic 1,3-dicarbonyl compounds and amino derivatives of phenyl pyrazoles and isoxazole and has been reported for the first time. This reaction occurred via a tandem oxidative-condensation reaction under microwave irradiation and notable characteristics of this protocol are MCR reactions, shorter reaction time, less waste creation, ease of workup, stable precursors, broad substrate scope and functional group tolerance.

SUBMITTER: Gowda D

PROVIDER: S-EPMC10545979 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature

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Microwave assisted one-pot access to pyrazolo quinolinone and tetrahydroisoxazolo quinolinone derivatives <i>via</i> T3P®-DMSO catalysed tandem oxidative-condensation reaction.

Gowda Darshini D Harsha Kachigere B KB Shalini Veeresha Gowda VG Rangappa Shobith S Rangappa Kanchugarakoppal S KS

RSC advances 20230901 40

A new approach for the synthesis of two important annulated pyrazolo quinolinone and tetrahydroisoxazolo quinolinone derivatives from multicomponent reactions was achieved by using T3P®-DMSO-catalysed reactions of stable alcohols, cyclic 1,3-dicarbonyl compounds and amino derivatives of phenyl pyrazoles and isoxazole and has been reported for the first time. This reaction occurred <i>via</i> a tandem oxidative-condensation reaction under microwave irradiation and notable characteristics of this ...[more]

PMID: 37795377

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