Alterations in the Fungal Microbiome in Ulcerative Colitis.

ABSTRACT:

Background

Although gut fungi have been implicated in the immunopathogenesis of inflammatory bowel disease, the fungal microbiome has not been deeply explored across endohistologic activity and treatment exposure in ulcerative colitis.

Methods

We analyzed data from the SPARC IBD (Study of a Prospective Adult Research Cohort with Inflammatory Bowel Disease) registry. We evaluated the fungal composition of fecal samples from 98 patients with ulcerative colitis across endoscopic activity (n = 43), endohistologic activity (n = 41), and biologic exposure (n = 82). Across all subgroups, we assessed fungal diversity and differential abundance of taxonomic groups.

Results

We identified 500 unique fungal amplicon sequence variants across the cohort of 82 patients, dominated by

SUBMITTER: Hsia K 

PROVIDER: S-EPMC10547232 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature