Photobiomodulation therapy activates YAP and triggers proliferation and dedifferentiation of Muller glia in mammalian retina.

ABSTRACT: Photobiomodulation therapy has been proposed as a promising therapeutic approach for retinal degenerative diseases. However, its effect on the regenerative capacity in mammalian retina and its intracellular signalling mechanisms remain unknown. Here, we show that photobiomodulation with 670 nm light stimulates Müller glia cell cycle re-entry and dedifferentiation into a progenitor-like state in both the uninjured and injured retina. We also find that 670 nm light treatment inhibits the Hippo pathway, which is activated in Müller glia following NaIO₃-induced retinal injury. YAP, a major downstream effector of the Hippo signalling pathway was translocated into the nucleus of Müller glia along with YAP dephosphorylation in retina treated with 670 nm light. Deficiency of YAP attenua

SUBMITTER: Kim SY 

PROVIDER: S-EPMC10547971 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature