Early Metformin in Gestational Diabetes: A Randomized Clinical Trial.

ABSTRACT:

Importance

Gestational diabetes is a common complication of pregnancy and the optimal management is uncertain.

Objective

To test whether early initiation of metformin reduces insulin initiation or improves fasting hyperglycemia at gestation weeks 32 or 38.

Design, setting, and participants

Double-blind, placebo-controlled trial conducted in 2 centers in Ireland (one tertiary hospital and one smaller regional hospital). Participants were enrolled from June 2017 through September 2022 and followed up until 12 weeks' postpartum. Participants comprised 510 individuals (535 pregnancies) diagnosed with gestational diabetes based on World Health Organization 2013 criteria.

Interventions

Randomized 1:1 to either placebo or metformin (maximum dose, 2500 mg) in addition

SUBMITTER: Dunne F 

PROVIDER: S-EPMC10548359 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature