The endometrial transcriptome transition preceding receptivity to embryo implantation in mice.

ABSTRACT:

Background

Receptivity of the uterus is essential for embryo implantation and progression of mammalian pregnancy. Acquisition of receptivity involves major molecular and cellular changes in the endometrial lining of the uterus from a non-receptive state at ovulation, to a receptive state several days later. The precise molecular mechanisms underlying this transition and their upstream regulators remain to be fully characterized. Here, we aimed to generate a comprehensive profile of the endometrial transcriptome in the peri-ovulatory and peri-implantation states, to define the genes and gene pathways that are different between these states, and to identify new candidate upstream regulators of this transition, in the mouse.

Results

High throughput RNA-sequencing was utilized t

SUBMITTER: Chan HY 

PROVIDER: S-EPMC10552439 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature