Two-dimensional shear wave elastography (ElastQ) accurately rules out liver fibrosis and rules in advanced chronic liver disease across liver disease etiologies: a prospective multicenter study.

ABSTRACT:

Purpose

This study evaluated ElastQ, a two-dimensional shear wave elastography (2D-SWE) technique, for the non-invasive assessment of liver fibrosis risk using liver stiffness measurement (LSM). The aim was to determine its diagnostic accuracy and establish LSM cutoffs for clinical risk stratification.

Methods

A prospective multicenter study was conducted, employing vibration-controlled transient elastography (VCTE) as a reference standard. The statistical analysis utilized Pearson correlations and Lin concordance correlation coefficients, diagnostic areas under the curve (AUCs), and 90%-specific rule-in and 90%-sensitive rule-out ElastQ cutoffs.

Results

The study included 875 patients at risk for liver disease, of whom 816 (376 women, 46.1%; median age, 57.0 years [i

SUBMITTER: Bauer DJM 

PROVIDER: S-EPMC10555684 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature