Proteome level analysis of drug-resistant Prevotella melaninogenica for the identification of novel therapeutic candidates.

ABSTRACT: The management of infectious diseases has become more critical due to the development of novel pathogenic strains with enhanced resistance. Prevotella melaninogenica, a gram-negative bacterium, was found to be involved in various infections of the respiratory tract, aerodigestive tract, and gastrointestinal tract. The need to explore novel drug and vaccine targets against this pathogen was triggered by the emergence of antimicrobial resistance against reported antibiotics to combat P. melaninogenica infections. The study involves core genes acquired from 14 complete P. melaninogenica strain genome sequences, where promiscuous drug and vaccine candidates were explored by state-of-the-art subtractive proteomics and reverse vaccinology approaches. A stringent bioinformati

SUBMITTER: Shah M 

PROVIDER: S-EPMC10556700 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature