MRNA-based vaccines and therapeutics: an in-depth survey of current and upcoming clinical applications.

ABSTRACT: mRNA-based drugs have tremendous potential as clinical treatments, however, a major challenge in realizing this drug class will promise to develop methods for safely delivering the bioactive agents with high efficiency and without activating the immune system. With regard to mRNA vaccines, researchers have modified the mRNA structure to enhance its stability and promote systemic tolerance of antigenic presentation in non-inflammatory contexts. Still, delivery of naked modified mRNAs is inefficient and results in low levels of antigen protein production. As such, lipid nanoparticles have been utilized to improve delivery and protect the mRNA cargo from extracellular degradation. This advance was a major milestone in the development of mRNA vaccines and dispelled skepticism about the potenti

SUBMITTER: Wang YS 

PROVIDER: S-EPMC10559634 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature