Harnessing CRISPR technology for viral therapeutics and vaccines: from preclinical studies to clinical applications.

ABSTRACT: The CRISPR/Cas system, identified as a type of bacterial adaptive immune system, have attracted significant attention due to its remarkable ability to precisely detect and eliminate foreign genetic material and nucleic acids. Expanding upon these inherent capabilities, recent investigations have unveiled the potential of reprogrammed CRISPR/Cas 9, 12, and 13 systems for treating viral infections associated with human diseases, specifically targeting DNA and RNA viruses, respectively. Of particular interest is the RNA virus responsible for the recent global outbreak of coronavirus disease 2019 (COVID-19), which presents a substantial public health risk, coupled with limited efficacy of current prophylactic and therapeutic techniques. In this regard, the utilization of CRISPR/Cas technology

SUBMITTER: Zahedipour F 

PROVIDER: S-EPMC10825633 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature