Identification of key immune cell-related genes involved in tumorigenesis and prognosis of cervical squamous cell carcinoma.

ABSTRACT: The infiltration of immune cells can significantly affect the prognosis and immune therapy of patients with cervical squamous cell carcinoma (CSCC). This study aimed to explore key immune cell-related genes in the tumorigenesis and prognosis of CSCC. The module significantly related to immunity was screened by weighted gene co-expression network analysis (WGCNA) and ESTIMATE analysis, followed by correlation analysis with clinical traits. Key candidate genes were intersected with the protein-protein interaction (PPI) network genes for immune-related genes. The relationship between immune cell infiltration and key genes was analyzed. Tumor immune dysfunction and exclusion (TIDE) and immunophenoscore (IPS) predicted the response to immunotherapy in CSCC patients. Clinically, quantitative rea

SUBMITTER: Yan C 

PROVIDER: S-EPMC10561582 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature