The HPV-TP53-MALAT1 Axis: Unravelling interactions in cervical cancer development.

ABSTRACT:

Introduction

Cervical cancer, primarily driven by Human Papillomavirus (HPV) infection, stands as a substantial global health challenge. The TP53 gene's, Arg72Pro polymorphism has emerged as a noteworthy player in cervical cancer development, particularly among individuals harboring high-risk (HR) HPV types. Additionally, long non-coding RNAs (lncRNAs), exemplified by metastasis-associated lung adenocarcinoma transcript 1 (MALAT1), exert critical roles in cancer biology. This study delves into unravelling the intricate connections linking HPV infection, TP53 Arg72Pro polymorphism, and MALAT1 expression in the context of cervical cancer.

Materials and methods

Within a cohort of cervical cancer patients, we discerned HPV infection statuses, executed genotyping for the TP53 Arg

SUBMITTER: Iordanishvili S 

PROVIDER: S-EPMC10561830 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature