Normative Modeling of Brain Morphometry in Clinical High Risk for Psychosis.

ABSTRACT:

Importance

The lack of robust neuroanatomical markers of psychosis risk has been traditionally attributed to heterogeneity. A complementary hypothesis is that variation in neuroanatomical measures in individuals at psychosis risk may be nested within the range observed in healthy individuals.

Objective

To quantify deviations from the normative range of neuroanatomical variation in individuals at clinical high risk for psychosis (CHR-P) and evaluate their overlap with healthy variation and their association with positive symptoms, cognition, and conversion to a psychotic disorder.

Design, setting, and participants

This case-control study used clinical-, IQ-, and neuroimaging software (FreeSurfer)-derived regional measures of cortical thickness (CT), cortical surface ar

SUBMITTER: ENIGMA Clinical High Risk for Psychosis Working Group 

PROVIDER: S-EPMC10568447 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature