Transgenerational epigenetic inheritance and immunity in chickens that vary in Marek's disease resistance.

ABSTRACT: Marek's disease virus (MDV), a naturally oncogenic, highly contagious alpha herpesvirus, induces a T cell lymphoma in chickens that causes severe economic loss. Marek's disease (MD) outcome in an individual is attributed to genetic and environmental factors. Further investigation of the host-virus interaction mechanisms that impact MD resistance is needed to achieve greater MD control. This study analyzed genome-wide DNA methylation patterns in 2 highly inbred parental lines 6₃ and 7₂ and 5 recombinant congenic strains (RCS) C, L, M, N, and X strains from those parents. Lines 6₃ and 7₂, are MD resistant and susceptible, respectively, whereas the RCS have different combinations of 87.5% Line 6₃ and 12.5% Line 7₂. Our DNA meth

SUBMITTER: He Y 

PROVIDER: S-EPMC10568563 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature