Risk prediction of second primary malignancies in patients after rectal cancer: analysis based on SEER Program.

ABSTRACT:

Background

This study will focus on exploring the clinical characteristics of rectal cancer (RC) patients with Second Primary Malignancies (SPMs) and constructing a prognostic nomogram to provide clinical treatment decisions.

Methods

We determined the association between risk factors and overall survival (OS) while establishing a nomogram to forecast the further OS status of these patients via Cox regression analysis. Finally, we evaluated the performance of the prognostic nomogram to predict further OS status.

Results

Nine parameters were identified to establish the prognostic nomogram in this study, and, the C-index of the training set and validation set was 0.691 (95%CI, 0.662-0.720) and 0.731 (95%CI, 0.676-0.786), respectively. The calibration curve showed a high

SUBMITTER: Sun YC 

PROVIDER: S-EPMC10568885 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature