Genetic Variants as Predictors of the Success of Colorectal Cancer Treatments.

ABSTRACT:

Background

Some genetic polymorphisms (SNPs) have been proposed as predictors for different colorectal cancer (CRC) outcomes. This work aims to assess their performance in our cohort and find new SNPs associated with them.

Methods

A total of 833 CRC cases were analyzed for seven outcomes, including the use of chemotherapy, and stratified by tumor location and stage. The performance of 63 SNPs was assessed using a generalized linear model and area under the receiver operating characteristic curve, and local SNPs were detected using logistic regressions.

Results

In total 26 of the SNPs showed an AUC > 0.6 and a significant association (p < 0.05) with one or more outcomes. However, clinical variables outperformed some of them, and the combination of genetic and cl

SUBMITTER: Garcia-Etxebarria K 

PROVIDER: S-EPMC10571592 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature