Alterations in Appetite-Regulating Hormones in Girls with Central Early or Precocious Puberty.

ABSTRACT: The prevalence of central precocious puberty (CPP) in girls has increased worldwide and is often associated with obesity in childhood as well as high fat/high glycemic index diets. Evidence suggests that subjects with obesity present with alterations in appetite-regulating hormones. The arcuate and paraventricular nuclei of the hypothalamus are the centers of action of appetite hormones, as well as the location of gonadotropin-releasing hormone (GnRH) neurons, the activation of which results in the onset of puberty. This anatomical proximity raises the question of possible alterations in appetite-regulating hormones in patients with CPP. Furthermore, diet-induced hypothalamic inflammation constitutes a probable mechanism of the pathophysiology of CPP, as well as alterations in appetite-reg

SUBMITTER: Stathori G 

PROVIDER: S-EPMC10574110 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature