Synthesis of L-Ornithine- and L-Glutamine-Linked PLGAs as Biodegradable Polymers.

ABSTRACT: L-ornithine and L-glutamine are amino acids used for ammonia and nitrogen transport in the human body. Novel biodegradable synthetic poly(lactic-co-glycolic acid) derivatives were synthesized via conjugation with L-ornithine or L-glutamine, which were selected due to their biological importance. L-ornithine or L-glutamine was integrated into a PLGA polymer with EDC coupling reactions as a structure developer after the synthesis of PLGA via the polycondensation and ring-opening polymerization of lactide and glycolide. The chemical, thermal, and degradation property-structure relationships of PLGA, PLGA-L-ornithine, and PLGA-L-glutamine were identified. The conjugation between PLGA and the amino acid was confirmed through observa

SUBMITTER: Taskor Onel G 

PROVIDER: S-EPMC10575337 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature