Bacillary Detachment in Neovascular Age-Related Macular Degeneration: Incidence, Clinical Features, and Response to Anti-VEGF Therapy.

ABSTRACT:

Objective

To evaluate the incidence of bacillary layer detachment among patients with neovascular age-related macular degeneration (nAMD) and their response to anti-VEGF therapy.

Design

Post hoc analysis of the OSPREY clinical trial, a prospective, double-masked, phase II study comparing 6-mg brolucizumab with 2-mg aflibercept over 56 weeks.

Participants

Participants with treatment-naive nAMD at the initiation of the trial were included in the analysis (n = 81).

Methods

Spectral-domain OCT (SD-OCT) scans were obtained at 4-week intervals throughout the OSPREY study and were segmented automatically using a proprietary, machine learning-enabled higher-order feature-extraction platform.

Main outcome measures

The presence of bacillary detachment, and in thes

SUBMITTER: Yordi S 

PROVIDER: S-EPMC10576655 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature