Diurnal Range and Intra-patient Variability of ACTH Is Restored With Remission in Cushing's Disease.

ABSTRACT:

Context

Single ACTH measurements have limited ability to distinguish patients with Cushing's disease (CD) from those in remission or with other conditions.

Objective

To investigate the changes in ACTH levels before and after transsphenoidal surgery (TSS) to identify trends that could confirm remission from CD and help establish ACTH cutoffs for targeted clinical trials in CD.

Design

Retrospective analysis of CD patients who underwent TSS from 2005 to -2019.

Setting

Referral center.

Patients

CD patients (n = 253) with ACTH measurements before and after TSS.

Interventions

TSS for CD.

Main outcome measures

Remission after TSS.

Results

Remission was observed in 223 patients after TSS. Those in remission had higher ACTH variability at AM

SUBMITTER: Alvarez R 

PROVIDER: S-EPMC10584004 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature