Ontology highlight
ABSTRACT:
SUBMITTER: Irie T
PROVIDER: S-EPMC10589698 | biostudies-literature | 2023 Oct
REPOSITORIES: biostudies-literature
Irie Takashi T Matsuda Taito T Hayashi Yoshinori Y Matsuda-Ito Kanae K Kamiya Akihide A Masuda Takahiro T Prinz Marco M Isobe Noriko N Kira Jun-Ichi JI Nakashima Kinichi K
Proceedings of the National Academy of Sciences of the United States of America 20231010 42
Although generating new neurons in the ischemic injured brain would be an ideal approach to replenish the lost neurons for repairing the damage, the adult mammalian brain retains only limited neurogenic capability. Here, we show that direct conversion of microglia/macrophages into neurons in the brain has great potential as a therapeutic strategy for ischemic brain injury. After transient middle cerebral artery occlusion in adult mice, microglia/macrophages converge at the lesion core of the str ...[more]