Striatal dopamine in anhedonia: A simultaneous [¹¹C]raclopride positron emission tomography and functional magnetic resonance imaging investigation.

ABSTRACT:

Background

Anhedonia is hypothesized to be associated with blunted mesocorticolimbic dopamine (DA) functioning in samples with major depressive disorder. The purpose of this study was to examine linkages between striatal DA, reward circuitry functioning, anhedonia, and, in an exploratory fashion, self-reported stress, in a transdiagnostic anhedonic sample.

Methods

Participants with (n = 25) and without (n = 12) clinically impairing anhedonia completed a reward-processing task during simultaneous positron emission tomography and magnetic resonance (PET-MR) imaging with [¹¹C]raclopride, a DA D2/D3 receptor antagonist that selectively binds to striatal DA receptors.

Results

Relative to controls, the anhedonia group exhibited decreased task-related DA release i

SUBMITTER: Phillips RD 

PROVIDER: S-EPMC10594643 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature