Neuronal connected burst cascades bridge macroscale adaptive signatures across arousal states.

ABSTRACT: The human brain displays a rich repertoire of states that emerge from the microscopic interactions of cortical and subcortical neurons. Difficulties inherent within large-scale simultaneous neuronal recording limit our ability to link biophysical processes at the microscale to emergent macroscopic brain states. Here we introduce a microscale biophysical network model of layer-5 pyramidal neurons that display graded coarse-sampled dynamics matching those observed in macroscale electrophysiological recordings from macaques and humans. We invert our model to identify the neuronal spike and burst dynamics that differentiate unconscious, dreaming, and awake arousal states and provide insights into their functional signatures. We further show that neuromodulatory arousal can mediate different mo

SUBMITTER: Munn BR 

PROVIDER: S-EPMC10611774 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature