The regulatory subunits of CK2 complex mediate DNA damage response and virulence in Candida Glabrata.

ABSTRACT:

Background

Candida glabrata which belongs to normal microbiota, has caused significant concern worldwide due to its high prevalence and drug resistance in recent years. C. glabrata has developed many strategies to evade the clearance of the host immune system, thereby causing persistent infection. Although coping with the induced DNA damage is widely acknowledged to be important, the underlying mechanisms remain unclear.

Results

The present study provides hitherto undocumented evidence of the importance of the regulatory subunits of CgCK2 (CgCkb1 and CgCkb2) in response to DNA damage. Deletion of CgCKB1 or CgCKB2 enhanced cellular apoptosis and DNA breaks and led to cell cycle delay. In addition, deficiencies in survival upon phagocytosis were observed in Δckb1 and Δckb2 str

SUBMITTER: Ni Q 

PROVIDER: S-EPMC10612253 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature