Dataset Information

Construction of prediction model for KRAS mutation status of colorectal cancer based on CT radiomics.

ABSTRACT:

Background

In this study, we used computed tomography (CT)-based radiomics signatures to predict the mutation status of KRAS in patients with colorectal cancer (CRC) and to identify the phase of radiomics signature with the most robust and high performance from triphasic enhanced CT.

Methods

This study involved 447 patients who underwent KRAS mutation testing and preoperative triphasic enhanced CT. They were categorized into training (n = 313) and validation cohorts (n = 134) in a 7:3 ratio. Radiomics features were extracted using triphasic enhanced CT imaging. The Boruta algorithm was used to retain the features closely associated with KRAS mutations. The Random Forest (RF) algorithm was used to develop radiomics, clinical, and combined clinical-radiomics models for KRAS mutations. The receiver operating characteristic curve, calibration curve, and decision curve were used to evaluate the predictive performance and clinical usefulness of each model.

Results

Age, CEA level, and clinical T stage were independent predictors of KRAS mutation status. After rigorous feature screening, four arterial phase (AP), three venous phase (VP), and seven delayed phase (DP) radiomics features were retained as the final signatures for predicting KRAS mutations. The DP models showed superior predictive performance compared to AP or VP models. The clinical-radiomics fusion model showed excellent performance, with an AUC, sensitivity, and specificity of 0.772, 0.792, and 0.646 in the training cohort, and 0.755, 0.724, and 0.684 in the validation cohort, respectively. The decision curve showed that the clinical-radiomics fusion model had more clinical practicality than the single clinical or radiomics model in predicting KRAS mutation status.

Conclusion

The clinical-radiomics fusion model, which combines the clinical and DP radiomics model, has the best predictive performance for predicting the mutation status of KRAS in CRC, and the constructed model has been effectively verified by an internal validation cohort.

SUBMITTER: Cao Y

PROVIDER: S-EPMC10613595 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature

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Publications

Construction of prediction model for KRAS mutation status of colorectal cancer based on CT radiomics.

Cao Yuntai Y Zhang Jing J Huang Lele L Zhao Zhiyong Z Zhang Guojin G Ren Jialiang J Li Hailong H Zhang Hongqian H Guo Bin B Wang Zhan Z Xing Yue Y Zhou Junlin J

Japanese journal of radiology 20230614 11

<h4>Background</h4>In this study, we used computed tomography (CT)-based radiomics signatures to predict the mutation status of KRAS in patients with colorectal cancer (CRC) and to identify the phase of radiomics signature with the most robust and high performance from triphasic enhanced CT.<h4>Methods</h4>This study involved 447 patients who underwent KRAS mutation testing and preoperative triphasic enhanced CT. They were categorized into training (n = 313) and validation cohorts (n = 134) in a ...[more]

PMID: 37311935

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Dataset Information

Construction of prediction model for KRAS mutation status of colorectal cancer based on CT radiomics.

Background

Methods

Results

Conclusion

Publications

Construction of prediction model for KRAS mutation status of colorectal cancer based on CT radiomics.

Similar Datasets

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