Subphenotypes in patients with acute respiratory distress syndrome treated with high-flow oxygen.

ABSTRACT:

Background

Acute respiratory distress syndrome (ARDS) subphenotypes differ in outcomes and treatment responses. Subphenotypes in high-flow nasal oxygen (HFNO)-treated ARDS patients have not been investigated.

Objectives

To identify biological subphenotypes in HFNO-treated ARDS patients.

Methods

Secondary analysis of a prospective multicenter observational study including ARDS patients supported with HFNO. Plasma inflammation markers (interleukin [IL]-6, IL-8, and IL-33 and soluble suppression of tumorigenicity-2 [sST2]) and lung epithelial (receptor for advanced glycation end products [RAGE] and surfactant protein D [SP-D]) and endothelial (angiopoietin-2 [Ang-2]) injury were measured. These biomarkers and bicarbonate were used in K-means cluster analysis to identify

SUBMITTER: Blot PL 

PROVIDER: S-EPMC10619276 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature