Overcoming barriers: a review on innovations in drug delivery to the middle and inner ear.

ABSTRACT: Despite significant advances in the development of therapeutics for hearing loss, drug delivery to the middle and inner ear remains a challenge. As conventional oral or intravascular administration are ineffective due to poor bioavailability and impermeability of the blood-labyrinth-barrier, localized delivery is becoming a preferable approach for certain drugs. Even then, localized delivery to the ear precludes continual drug delivery due to the invasive and potentially traumatic procedures required to access the middle and inner ear. To address this, the preclinical development of controlled release therapeutics and drug delivery devices have greatly advanced, with some now showing promise clinically. This review will discuss the existing challenges in drug development for treating the m

SUBMITTER: Delaney DS 

PROVIDER: S-EPMC10620978 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature