Cystatin C as a GFR Estimation Marker in Acute and Chronic Illness: A Systematic Review.

ABSTRACT:

Rationale & objective

Creatinine-based GFR estimating (eGFRcr) equations may be inaccurate in populations with acute or chronic illness. The accuracy of GFR equations that use cystatin C (eGFRcys) or creatinine-cystatin C (eGFRcr-cys) is not well studied in these populations.

Study design

A systematic review of original articles identified from PubMed and expert sources. Two reviewers screened articles independently and identified those meeting inclusion criteria.

Setting & study populations

Adults and children with acute or chronic illness.

Selection criteria for studies

Studies published since 2011 that compared performance of eGFRcr, eGFRcys, and eGFRcr-cys relative to measured GFR (mGFR), used standardized assays for creatinine or cystatin C, and used eGFR

SUBMITTER: Adingwupu OM 

PROVIDER: S-EPMC10623366 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature