Accurate GFR in obesity-protocol for a systematic review.

ABSTRACT:

Background

Obesity is increasing globally. Chronic kidney disease (CKD) is strongly associated with obesity. Kidney function is commonly estimated with equations using creatinine (such as CKD-EPI equation) which is a product of muscle metabolism. Decisions about categorizing CKD, planning modality of renal replacement therapies, and adjusting dosages of medications excreted by the kidneys are done using these equations. However, it is not well appreciated that creatinine-based equations may not accurately estimate kidney function in obese individuals. We plan a systematic review of diagnostic studies which will compare estimating equations to actual measured kidney function.

Methods

We will systematically search electronic bibliographic databases including MEDLINE, EMBASE, a

SUBMITTER: Sriperumbuduri S 

PROVIDER: S-EPMC6588895 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature