Discordance Between Creatinine-Based and Cystatin C-Based Estimated GFR: Interpretation According to Performance Compared to Measured GFR.

ABSTRACT:

Rationale & objective

Use of cystatin C in addition to creatinine to estimate glomerular filtration rate (estimated glomerular filtration rate based on cystatin C [eGFRcys] and estimated glomerular filtration rate based on creatinine [eGFRcr], respectively) is increasing. When eGFRcr and eGFRcys are discordant, it is not known which is more accurate, leading to uncertainty in clinical decision making.

Study design

Cross-sectional analysis.

Setting & participants

Four thousand fifty participants with measured glomerular filtration rate (mGFR) from 12 studies in North America and Europe.

Exposures

Serum creatinine and serum cystatin C.

Outcomes

Performance of creatinine-based and cystatin C-based glomerular filtration rate estimating equations compared to

SUBMITTER: Wang Y 

PROVIDER: S-EPMC10518599 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature