Integrated treatment guided by RNA-seq-based endometrial receptivity assessment for infertility complicated by MEN1.

ABSTRACT:

Background

Preimplantation genetic testing (PGT) serves as a tool to avoid genetic disorders in patients with known genetic conditions. However, once a selected embryo is transferred, implantation success is attained independent of embryo quality. Using PGT alone is unable to tackle implantation failure caused by endometrial receptivity (ER) abnormalities in these patients.

Methods

We validated our newly developed RNA-seq-based ER test (rsERT) in a retrospective cohort study including 511 PGT cycles and reported experience in treating an infertile female patient complicated by multiple endocrine neoplasia type 1 (MEN1).

Results

Significant improvement in the clinical pregnancy rate was found in the performed personalized embryo transfer (pET) group (CR, 69.7%; P

SUBMITTER: Huang X 

PROVIDER: S-EPMC10623411 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature