Decreased Alu methylation in type 2 diabetes mellitus patients increases HbA1c levels.

ABSTRACT:

Introduction

Alu hypomethylation is a common epigenetic process that promotes genomic instability with aging phenotypes, which leads to type 2 diabetes mellitus (type 2 DM). Previously, our results showed significantly decreased Alu methylation levels in type 2 DM patients. In this study, we aimed to investigate the longitudinal changes in Alu methylation levels in these patients.

Results

We observed significantly decreased Alu methylation levels in type 2 DM patients compared with normal (p = 0.0462). Moreover, our findings demonstrated changes in Alu hypomethylation over a follow-up period within the same individuals (p < 0.0001). A reduction in Alu methylation was found in patients with increasing HbA1c levels (p = 0.0013) and directly correlated with increased HbA1c leve

SUBMITTER: Thongsroy J 

PROVIDER: S-EPMC10623537 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature