A Fenton Approach to Aromatic Radical Cations and Diarylmethane Synthesis.

ABSTRACT: Manipulating carbon-centered radicals to add to electron-deficient systems is a well-precedented process. By coupling the Fe(II)-mediated Fenton reaction with the Fe(III)-mediated single-electron oxidation of anisolic compounds, we demonstrate how electron-rich carbon-centered radicals can react with electron-rich arenes through a radical-polar cascade pathway. This bioinspired approach produces diarylmethane derivatives from simple unfunctionalized precursors.

SUBMITTER: Iii RC 

PROVIDER: S-EPMC10629232 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature