Istradefylline effects on tremor dominance (TD) and postural instability and gait difficulty (PIGD).

ABSTRACT:

Background

In patients with Parkinson's Disease (PD), two distinct motor subtypes, tremor dominant (TD) and postural instability and gait difficulty (PIGD), can be differentiated using Unified Parkinson's Disease Rating Scale (UPDRS) sub-scores. This post hoc analysis of pooled data from eight pivotal studies examined the effect of treatment with istradefylline, a selective adenosine A_2A receptor antagonist, on these subtypes.

Methods

In eight randomized, placebo-controlled phase 2b/3 trials, patients on levodopa with carbidopa/benserazide experiencing motor complications received istradefylline (20 or 40 mg/day) or placebo for 12 or 16 weeks. TD subtype was defined by the UPDRS II/III items kinetic and postural tremor in right/left hand and (resting) tremo

SUBMITTER: Torres-Yaghi Y 

PROVIDER: S-EPMC10630111 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature