Targeting histone deacetylase suppresses tumor growth through eliciting METTL14-modified m⁶ A RNA methylation in ocular melanoma.

ABSTRACT:

Background

Diversified histone deacetylation inhibitors (HDACis) have demonstrated encouraging outcomes in multiple malignancies. N6-methyladenine (m⁶ A) is the most prevalent messenger RNA modification that plays an essential role in the regulation of tumorigenesis. Howbeit, an in-depth understanding of the crosstalk between histone acetylation and m⁶ A RNA modifications remains enigmatic. This study aimed to explore the role of histone acetylation and m⁶ A modifications in the regulation of tumorigenesis of ocular melanoma.

Methods

Histone modification inhibitor screening was used to explore the effects of HDACis on ocular melanoma cells. Dot blot assay was used to detect the global m⁶ A RNA modification level. Multi-omics assays

SUBMITTER: Zhuang A 

PROVIDER: S-EPMC10631484 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature