Copine7 deficiency leads to hepatic fat accumulation via mitochondrial dysfunction.

ABSTRACT:

Objective

Mitochondrial dysfunction affects hepatic lipid homeostasis and promotes ROS generation. Copine7 (CPNE7) belongs to the ubiquitous copine family of calcium-dependent phospholipid binding proteins. CPNE7 has a high calcium ion binding affinity and the capacity to scavenge reactive oxygen species (ROS). A recent study reported that abnormalities in fatty acid and lipid metabolism were linked to the gene variant of CPNE7. Therefore, the purpose of this study is to examine the role of Cpne7 in hepatic lipid metabolism based on mitochondrial function.

Methods

Lipid metabolism, mitochondrial function, and ROS production were investigated in high-fat diet (HFD)-fed Cpne7^-/- mice and H₂O₂-damaged HepG2 hepatocytes following CPNE7<

SUBMITTER: Hwang G 

PROVIDER: S-EPMC10637907 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature