Diatomic iron nanozyme with lipoxidase-like activity for efficient inactivation of enveloped virus.

ABSTRACT: Enveloped viruses encased within a lipid bilayer membrane are highly contagious and can cause many infectious diseases like influenza and COVID-19, thus calling for effective prevention and inactivation strategies. Here, we develop a diatomic iron nanozyme with lipoxidase-like (LOX-like) activity for the inactivation of enveloped virus. The diatomic iron sites can destruct the viral envelope via lipid peroxidation, thus displaying non-specific virucidal property. In contrast, natural LOX exhibits low antiviral performance, manifesting the advantage of nanozyme over the natural enzyme. Theoretical studies suggest that the Fe-O-Fe motif can match well the energy levels of Fe₂ minority β-spin d orbitals and pentadiene moiety π* orbitals, and thus significantly lower the activation

SUBMITTER: Li B 

PROVIDER: S-EPMC10640610 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature